Effect of Metformin Treatment and Insulin Resistance in Patients with Polycystic Ovary Syndrome
Abstract
Objective : This study was performed to investigate the effect of metformin treatment and insulin resistance in the patients with polycystic ovary syndrome. Methods : Twenty three patients with polycystic ovary syndrome were included at Seoul National University Hospital from September 2001 to September 2003. Metformin was administered at daily 1,500 mg for 3 months to these patients. Then restoration of regular menstruation or recovery of ovulation was evaluated and insulin resistance was compared between the responder and the non- responder before and after metformin treatment. Results : Eleven patients (47.8%) showed a significant improvement in menstrual or ovulation cyclicity whereas twelve patients had no change. There was no statistically significant difference in the insulin resistance between the responder and the non-responder before and after metformin treatment. Conclusion : In non-obese patients with polycystic ovary syndrome, metformin treatment seems to be effective to improvement of menstrual or ovulation cyclicity irrespective of insulin resistance expressed as glucose-to- insulin ratio and HOMA.
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