Effect of Metformin on the LH and FSH levels in Obese Patients with Polycystic Ovary Syndrome
Abstract
Objective: To study the effect of metformin on the LH and FSH levels in obese patients with polycystic ovary syndrome(PCOS).Methods: A total of 84 obese patients with PCOS were randomly divided into two groups: 44 cases in control group(clomiphene citrate) and 40 cases in observation group(metformin).The radioimmunoassay was used to detect the levels of luteinizing hormone(LH) and follicle stimulating hormone(FSH).Blood were collected respectively before treatment(0 min) and 60,120 minutes after taking medication via the forearm vein to measure the blood glucose and serum insulin levels.Results: In the control group,OGTT glucose level of patients at 0 min,60min and 120min before treatment were(4.57±0.25) mmol/L,(8.38±7.05) mmol/L and(7.21±0.12) mmol/L,respectively;there were no significant changes of OGTT blood glucose levels of patients at 0min,60min and 120min after treatment.In the observation group,the OGTT glucose level of patients at 0min,60min and 120min before treatment were respectively(4.11±0.31) mmol/L,(8.23±6.57) mmol/L and(7.25±0.13) mmo l/L;but the OGTT blood glucose level decreased significantly at 0min,60min and 120min after treatment.In the control group,serum insulin was(47.32±9.52) U/ml in patients before treatment,and(42.25±7.65) U / ml in patients after treatment,with no significant difference before and after treatment.In the observation group,the serum insulin in patients before treatment was(46.41±6.11) U / ml,and was significantly decreased after…
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