Clinical Observation of Marvelon Combined with Metformin in Infertile Patients with Polycystic Ovary Syndrome
Abstract
Objective: To evaluate the therapeutic effects of marvelon combined with metformin in infertile patients with polycystic ovary syndrome(PCOS).Methods: Eighty-two infertile patients with PCOS were randomly divided into test group(taking marvelon(one tablet a day for 21 days)plus metformin(at dosage of 500 mg,three times a day),detecting the levels of sex hormone before and after therapy,measuring waist hip ratio(WHR)and body mass index(BMI))and control group(adjusting the lifeway and completing some tests).The ovulation induction treated by clomiphene was conducted between two groups.Results: The clinical symptoms(P0.01 or P0.05)and the levels of sex hormone(P0.01)in the test group were improved obviously,WHR and BMI were decreased.Compared with the control group,the cycle ovulation and clinical pregnancy rates in the test group were increased obviouly(P0.05 or P0.01).Conclusion: Marvelon with metformin before inducing ovulation can effectively improve hyperandrogenism and insulin resistance in infertile patients with PCOS,and further enhance the induced ovulation and clinical pregnancy rates.
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