Beyond opioids: FDA-approved suzetrigine offers hope for acute pain management
Abstract
The opioid epidemic is an ongoing public health crisis that has affected millions of people all over the world over the past two decades. It was officially declared a Public Health Emergency by the U.S. Department of Health and Human Services in 2017 and unfortunately has claimed the lives of hundreds of thousands of Americans. A recent WHO pharmacovigilance analysis reveals a substantial burden of opioid-related adverse drug reactions in high-income countries such as the United States, United Kingdom, Canada, and Australia, while suggesting widespread underreporting in low and middle-income regions [1] . The consequences of the opioid crisis are severe. Opioid-related mortality has increased significantly in recent years, with region-specific death tolls revealing the widespread nature of the epidemic. In the United States, the CDC’s State Unintentional Drug Overdose Reporting System recorded 51 435 overdose deaths in 2022 [2] . On a global scale, approximately 60 million people are affected by addiction to prescription opioids, including hydroco-done, methadone, meperidine, oxycodone, and fentanyl. More than 100 000 individuals die each year from opioid overdoses worldwide. These figures reflect a pressing need for safer, non-addictive alternatives to address acute pain without contributing to the cycle of dependence and harm [3] . Opioids are a class of drugs primarily
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