Effects of testosterone and metformin on glucose metabolism in endometrium
Abstract
OBJECTIVE: To investigate the effects of testosterone and metformin on glucose metabolism in endometrium.
DESIGN: In vitro experiment.
SETTING: Reproductive and Genetic Center, Obstetrics and Gynecology, The First Hospital of Peking University, Beijing, China.
PATIENT(S): Premenopausal women undergoing total abdominal hysterectomy for uterine myoma or adenomyosis.
INTERVENTION(S): Endometrial glandular epithelial cell culture.
MAIN OUTCOME MEASURE(S): Insulin receptor substrate-1 (IRS-1) and glucose transporter 4 (GLUT-4) expression in endometrial glandular epithelial cell.
RESULT(S): After the action of testosterone solution, the protein expressions of IRS-1mRNA, IRS-1, and GLUT-4 in endometrial glandular epithelial cells all decreased significantly. Metformin may reverse this effect.
CONCLUSION(S): The high androgen levels in patients with polycystic ovary syndrome could induce insulin resistance in endometrial glandular epithelial cell, whereas metformin has an antagonizing effect.
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