Integrating evidence-based lifestyle and adjunct therapies for long-term management of polycystic ovary syndrome: mechanistic insights and clinical implications
Abstract
Background: Polycystic ovary syndrome (PCOS) is a complex multisystem disorder affecting 6%-13% of reproductive-aged women, characterized by hormonal and metabolic dysregulation. Driven by hyperandrogenism and insulin resistance, it contributes to reproductive and cardiometabolic complications. Current management remains largely symptom-focused, often limiting long-term effectiveness and comprehensive disease control.
Objective and rationale: This narrative review critically evaluates current evidence on lifestyle-based and adjunct therapeutic strategies in PCOS management, with emphasis on dietary interventions, physical activity, nutraceuticals, and traditional remedies, focusing on their potential to modulate metabolic, endocrine, and inflammatory pathways alongside conventional clinical treatments.
Search strategy: A structured narrative literature search was conducted across PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar to identify studies published in English-language. Keywords related to PCOS, insulin resistance, hyperandrogenism, oxidative stress, lifestyle-interventions, dietary strategies, physical activity, traditional medicine, phytotherapy and mind-body interventions were combined using Boolean operators. Relevant original studies, clinical trials, systematic reviews, and meta-analyses were selected based on scope and relevance.
Key findings: Emerging evidence highlights the multifaceted role of lifestyle and adjunct interventions in improving the…
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