Effect of metformin on the outcomes of immature oocytes in vitro maturation in patients with polycystic ovary syndrome
Abstract
Objective:To evaluate the effect of metformin on related outcomes of immature oocytes in vitro maturation (IVM) in patients with polycystic ovary syndrome (PCOS).Methods:75 infertile women (106 cycles) with intractable PCOS receiving IVM in the center from August 2005 to August 2007 were selected,then the women were divided into A group (16 women of 20 cycles),B group (15 women of 23 cycles) and C group (without any treatment,44 women of 63 cycles) according to adding metformin or not and different therapeutic methods;the effects of metformin on IVM related outcomes were compared.Results:There was no significant difference in the number of retrieved oocytes,fertilization rate,cleavage rate,implantation rate,clinical pregnancy rates of puncture cycle and implantation cycle among the three groups (P0.05);there was no significant difference in IVM rate of oocytes,number of excellent embryos and number of transfer embryos per cycle between A group and B group,but the above indexes in A group and B group were significantly higher than those in C group (P0.05);the abortion rates of A group,B group and C group were 0.00%,14.30% and 20.00%,respectively,there was significant difference between A group and C group (P0.05).Conclusion:IVM is an effective technique for intractable PCOS patients to get a high pregnancy rate,and metformin therapy may improve the outcome of IVM.
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