Polycystic ovary syndrome and fertility
Abstract
The fertility issues in patients with polycystic ovary syndrome remain perplexing for clinicians and frustrating for patients. They account for approximately 75% of all women with anovulation or approximately 30% of all women with infertility, and US$533 million was spent on fertility treatment, as it was estimated in 2005 [1]. Women with polycystic ovary syndrome have reduced ovulation rates [2] and thus problems with achieving pregnancies and live births. Frequently there is an increased risk for miscarriages and other pregnancy complications (gestational diabetes mellitus, preterm delivery, preeclampsia and eclampsia, and fetal macrosomia). The therapy for fertility traditionally includes ovulation induction with clomifene, follicle-stimulating hormone/β-human chorionic gonadotropin injections, in vitro fertilization or intracytoplasmic sperm injection, surgical intervention (ovarian drilling, wedge resection and such) and, over the last decade or so, metformin.
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