The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction
Abstract
INTRODUCTION
The serendipitous discovery of sildenafil (Viagra [sildenafil citrate]) as a treatment for erectile dysfunction (ED) is one of the most fascinating drug development stories of our time. When sildenafil was approved by the U.S. Food and Drug Administration in 1998, it revolutionized the treatment protocol for men with ED, once considered a psychological issue or an inevitable part of aging.
AIM
To review the discovery of sildenafil and its role in changing the field of sexual medicine in the context of the epidemiology and history of treatment for ED.
METHODS
For this narrative review, a literature search was conducted to identify essential articles and was supplemented by author observations from a historical perspective.
MAIN OUTCOME MEASURE
A broad overview of ED and its past, current, and future treatments.
RESULTS
ED is a prevalent condition for which medical treatment had been limited to genitally localized interventions, including surgery, vacuum pumps, injectable therapies, and intraurethral suppositories. The discovery of sildenafil provided a safe, oral pharmacotherapy for the treatment of ED, sparking greater understanding of the science behind ED and its role in men's overall health.
CONCLUSION
The approval of sildenafil initiated a global conversation about ED that had profound implications for patients, methods of clinical practice, and academic sexual medicine. These changes will catalyze continued advances in ED treatment. Goldstein I, Burnett AL,…
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