Black pepper (Piper nigrum L.) fruit extract ameliorates erectile dysfunction in alloxan-induced diabetic rats
Abstract
Background Diabetes mellitus (DM) is a chronic metabolic disorder frequently associated with male sexual and reproductive dysfunction, including erectile dysfunction (ED), reduced libido, and impaired spermatogenesis. Black pepper ( Piper nigrum L.) fruit extract has been reported to possess antidiabetic and reproductive benefits, yet its effect on DM-related ED remains underexplored. Objective To evaluate the effects of Piper nigrum fruit extract on erectile function, libido, sperm parameters, and testicular histology in alloxan-induced diabetic male rats. Methods Thirty male Sprague Dawley rats were divided into five groups: normal control, diabetic control, diabetic rats treated with black pepper extract (122.5 or 245 mg/kg BW), and diabetic rats treated with sildenafil citrate. Erectile function was assessed via penile reflexes, libido by mating behavior, sperm quality by concentration, motility, and morphology, and testicular histology by Leydig cell and spermatogonia counts. Data were analyzed using ANOVA with significance at p<0.05. Results Alloxan-induced diabetic rats showed significant impairment in erectile function, libido, sperm quality, and testicular histology (p<0.001 vs control). Black pepper extract at 122.5 mg/kg BW significantly improved total penile reflexes compared with diabetic controls (9.33±1.03 vs 6.00±1.26, p=0.02). Libido parameters including courtship latency (5.50±0.55 vs 21.00±9.47, p=0.013), mount latency (19.00±10.81 vs 37.17±6.31, p=0.009),…
How strong is the evidence?
Evidence Hub reads this as a preprint, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- 2024 update in heart failure
- Vascular involvement in idiopathic pulmonary fibrosis
- A novel technique- subendometrial autologous platelet rich plasma injection in patients with unresponsive thin endometrium undergoing frozen-thawed embryo transfer: a prospective cohort study
- Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial
- Combined Pulmonary Fibrosis and Emphysema (CPFE): A "New" Smoking-Related Interstitial Lung Disease (ILD)
- Impact of an acute 1-month cannabidiol treatment on pain and inflammation after a long bone fracture: a triple-blind randomised, placebo-controlled, clinical trial protocol
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.