Association between tricuspid regurgitant pressure and heart failure severity in children with acyanotic congenital heart disease receiving sildenafil therapy
Abstract
Background. Acyanotic congenital heart defects (ACHD) often lead to right ventricular volume overload and elevated pulmonary pressures, contributing to pediatric heart failure. Tricuspid regurgitant pressure (TRP) estimated by echocardiography serves as a non-invasive marker of pulmonary hypertension and right-sided heart stress. Sildenafil, a phosphodiesterase-5 inhibitor, is commonly used to lower pulmonary vascular resistance in children with congenital heart disease. The purpose was to evaluate the correlation between echocardiographic TRP and the severity of pediatric heart failure, as measured by the Modified Ross Score, in children with ACHD receiving sildenafil therapy. Materials and methods. A cross-sectional observational study was conducted in 45 children with ACHD and clinical signs of heart failure at Dr. Soetomo General Hospital between January and May 2025. TRP was assessed via Doppler echocardiography, and heart failure severity was quantified using the Modified Ross Score. Data were analyzed using Pearson correlation and multiple linear regression. Results. TRP showed a moderate positive correlation with the Modified Ross Score (r = 0.401, p = 0.006). TRP > 38 mmHg was predictive of more severe heart failure and malnutrition. Sildenafil therapy was used for > 3 months in 66.7 % of patients. A regression model indicated TRP as an independent predictor of heart failure severity (β = 0.030, p = 0.007), while body weight had no significant effect. Conclusions.…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 45 participants or records.
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