Toxicity tests of exposure to sildenafil, dicloxacillin, and ibuprofen of Eisenia fetida
Abstract
Due to their extensive and ongoing use, inappropriate disposal, and partial removal in wastewater treatment facilities, pharmaceutical compounds have become major environmental contaminants. These compounds are commonly found in surface and wastewater, and pharmaceuticals can build up in the terrestrial environment when contaminated water is used again for soil replenishment or agricultural irrigation. The possible ecotoxicological effects on soil organisms, especially invertebrates, which are essential to preserving soil health and ecosystem functioning, are a cause for concern in light of this phenomenon. Three pharmaceutical substances: ibuprofen, dicloxacillin, and sildenafil, were chosen for this study due to their high rates of consumption, accessibility, and environmental significance. Ecotoxicity tests were performed following Economic Cooperation and Development Protocol 207, using Eisenia fetida as a study organism, to evaluate the impact of emerging contaminants from the pharmaceutical subgroup sildenafil, dicloxacillin, and ibuprofen. The study included both contact tests in Petri dishes and tests with artificial soil to assess the lethal concentration 50 (LC50) of these substances. The results indicated that ibuprofen exhibited the highest toxicity of the three tested pharmaceuticals, demonstrating significantly more lethal effects on Eisenia fetida in both types of tests than the other two substances evaluated. The LC50 values obtained in the study were 7.53…
Read the paper
Related studies
- 2024 update in heart failure
- Vascular involvement in idiopathic pulmonary fibrosis
- A novel technique- subendometrial autologous platelet rich plasma injection in patients with unresponsive thin endometrium undergoing frozen-thawed embryo transfer: a prospective cohort study
- Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial
- Combined Pulmonary Fibrosis and Emphysema (CPFE): A "New" Smoking-Related Interstitial Lung Disease (ILD)
- Impact of an acute 1-month cannabidiol treatment on pain and inflammation after a long bone fracture: a triple-blind randomised, placebo-controlled, clinical trial protocol
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.