Effective Role of Oral Sildenafil in the Treatment of Cystic Hygroma in an Infant: A Case Report
Abstract
Cystic hygroma is a benign congenital malformation of the lymphatic system. Most cystic hygromas are found in the neck; rarer locations include the axilla, mediastinum, and limbs. Symptoms range from incidental findings to significant morbidity due to compression of adjacent organs, infection, haemorrhage, etc. Treatment is primarily aimed at complete surgical resection. Other treatment modalities include sclerotherapy, radiotherapy, laser ablation, and medical therapy with sirolimus, but recurrence rates are high. Surgery is not always possible since Lymphatic Malformations (LMs) can be intertwined within muscles or organs, and incomplete resection of LMs can result in recurrence; hence, alternative therapies have been explored. Recently, authors reported a case of a full-term female infant with a left-sided cystic hygroma. There was marked regression of the cystic hygroma with oral sildenafil, a selective inhibitor of phosphodiesterase-5.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- 2024 update in heart failure
- Vascular involvement in idiopathic pulmonary fibrosis
- A novel technique- subendometrial autologous platelet rich plasma injection in patients with unresponsive thin endometrium undergoing frozen-thawed embryo transfer: a prospective cohort study
- Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial
- Combined Pulmonary Fibrosis and Emphysema (CPFE): A "New" Smoking-Related Interstitial Lung Disease (ILD)
- Impact of an acute 1-month cannabidiol treatment on pain and inflammation after a long bone fracture: a triple-blind randomised, placebo-controlled, clinical trial protocol
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.