(390) Combining a Nitric Oxide Boosting Dietary Supplement With Sildenafil Improves Nighttime Erections More Than Sildenafil Alone
Abstract
Abstract Introduction Nitric Oxide boosting supplements improve circulation by increasing cGMP. PDE-5 inhibitors work by blocking PDE- 5, which increases NO mediated blood flow to the penis by enhancing cyclic GMP. There is limited objective data on the synergistic effects of NO boosting dietary supplements and PDE-5 inhibitors. The NO boosting dietary supplement used in this study consists of L-citrulline, Red Beet Root extract, Panax Ginseng Root Extract, and Muira Puama Extract. The kidneys convert L-citrulline into Arginine, which produces NO that relaxes blood vessels and improves blood flow. Beetroot extract has a high nitrate content, which the body converts into NO. Nighttime erections can be measured and provide an objective indicator of erectile health. Objective We investigated whether ingesting a NO boosting dietary supplement and Sildenafil 40 mg one hour before sleep can improve nighttime erectile function compared to Sildenafil 40 alone by using the TechRing by FirmTech to measure penile pressure while sleeping. Methods 22 men completed the study. Average age 55. Average SHIM score 18.1. A single tablet of the NO boosting dietary supplement contains 750 mg L-Citrulline, 65 mg Muira Puama Extract 4:1, Red Beet Root extract 45mg 4:1, Panax Ginseng Root Extract 35mg 4:1. This supplement is commercially available as AFFIRM. Participants wore the TechRing during sleep to measure nighttime erectile function. The TechRing uses two sensors and an AI interface to…
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