Study of the effect of sildenafil citrate and letrozole on endometrial thickness in infertility patients in a tertiary care hospital in eastern india
Abstract
Background: Sildenafil is responsible for vascular smooth muscle relaxation and increased blood flow to the endometrium. This results in better
endometrial thickness and receptivity and improvement in implantation of the embryos. Objective: Evaluation of the efficacy of vaginal sildenafil
on the endometrial thickness and pregnancy outcomes in letrozole induced ovulation induction cycles. Materials And Methods: 102 infertile
women were included in this prospective study. The women were allocated to two groups – Group A and Group B. Letrozole was used to induce
ovulation in all these 102 women. Vaginal sildenafil twice daily was added to women of Group B from Day-8 of menstrual cycle till the day of hCG
trigger. All women underwent follicular monitoring on Day-12 of menstrual cycle. If the follicle size was not adequate, then a repeat follicle scan
was done after 2 days. Injection urinary hCG 5,000 IU IM was given as trigger. A timed intercourse was advised. On Day-30, a urine β-hCG was
done to identify a positive pregnancy. Result: The mean endometrial thickness on the day of hCG trigger in women of Group B, i.e women who
received sildenafil was 9.8 mm compared to 8.4 mm in Group A , i.e women without sildenafil. Pregnancy rate in women who received sildenafil
was 62.7% , compared to 49.01% in women who did not receive sildenafil. Conclusion: Use of vaginal sildenafil in women undergoing letrozole
induced ovulation induction cycles helps in improving endometrial thickness and…
Read the paper
Related studies
- 2024 update in heart failure
- Vascular involvement in idiopathic pulmonary fibrosis
- A novel technique- subendometrial autologous platelet rich plasma injection in patients with unresponsive thin endometrium undergoing frozen-thawed embryo transfer: a prospective cohort study
- Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial
- Combined Pulmonary Fibrosis and Emphysema (CPFE): A "New" Smoking-Related Interstitial Lung Disease (ILD)
- Impact of an acute 1-month cannabidiol treatment on pain and inflammation after a long bone fracture: a triple-blind randomised, placebo-controlled, clinical trial protocol
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.