Role of platelet-rich plasma in unexplained recurrent implantation failure: an umbrella review
Abstract
Background/objective: The role of platelet-rich plasma (PRP) in assisted reproductive technology is being explored, particularly in cases of recurrent implantation failure (RIF). The objective of our study is to thoroughly synthesise and critically assess the available evidence from systematic reviews and meta-analyses regarding the use of PRP in women with unexplained RIF.
Methods: A thorough web search was performed on Medline, PubMed, EMBASE, Web of Science, OVID, JBI Evidence Synthesis, the Cochrane Database of Systematic Reviews, DARE, and the PROSPERO register to identify systematic reviews addressing the research question. Systematic reviews were assessed based on their "explicit, reproducible methodology," comprehensive search strategy, acceptable methods for assessing the validity of included studies, evaluation of the risk of bias, and assessment of the certainty of the evidence. The methodological quality was assessed with the AMSTAR tool comprising 11 items. Before compiling the results, a corrected covered area (CCA) metric was used to evaluate the degree of overlap. Data extraction included descriptive variables and details about the intervention and outcomes.
Results: A total of 15 systematic reviews of randomised controlled trials are included. The CCA matrix revealed very high overlap (42%). Although our study showed an improvement in implantation rate, clinical pregnancy rate, and live birth rate, the certainty of evidence was either low or not reported.…
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