(463) Efficacy of Low-Intensity Shockwave Therapy in Erectile Dysfunction (2010–2025): A Systematic Review
Abstract
• Erectile Dysfunction (ED): A persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance, affecting ~30–65% of men aged 40–80. Conventional ED therapies include lifestyle modifications, psychosocial counseling, and oral phosphodiesterase-5 inhibitors (e.g., sildenafil). However, a significant subset of patients do not respond adequately to these treatments and may experience side effects (e.g. flushing, headache). • LI-ESWT as a Novel Therapy: Low-intensity extracorporeal shockwave therapy (LI-ESWT) has emerged in the last decade as a non-invasive, regenerative treatment alternative for ED. Unlike high-energy shockwaves used for lithotripsy, low-intensity shockwaves are thought to stimulate neoangiogenesis (new blood vessel formation) and improve penile blood flow, aiming for more durable improvements in erectile function. Preclinical and early clinical studies reported enhanced penile hemodynamics after LI-ESWT, sparking growing interest in this therapy.
• Objective: This work is a PRISMA-guided systematic review (2010–2025) evaluating the efficacy and safety of LI-ESWT for male ED. We synthesized evidence across all severities and age groups, focusing on clinical outcomes (erectile function scores, erection hardness, successful intercourse rates) and adverse events.
Methods • Literature Search: A comprehensive search was conducted in multiple databases (Google Scholar, Virtual Health Library/BVS, SciELO, and CAPES journals…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 1,064 participants or records.
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