Nosocomial Pneumonia in Georgia: A Study of Extended Spectrum Beta-Lactamase (ESBL)-Producing Versus Non-extended ESBL Gram-Negative Bacterial Profiles
Abstract
BACKGROUND: Nosocomial pneumonia is a significant healthcare challenge, particularly in the face of rising antimicrobial resistance among Gram-negative bacteria. The production of extended spectrum beta-lactamase (ESBL) exacerbates treatment complexities. AIM: This study investigates the prevalence and resistance patterns of ESBL-producing and non-ESBL Gram-negative bacteria in nosocomial pneumonia cases in Georgian hospitals to inform antibiotic stewardship and treatment strategies. To our knowledge, this is the first study of its kind conducted in Georgia, offering critical insights into bacterial resistance in this region. METHODS: This prospective observational study analyzed a total of 357 pulmonary samples from patients diagnosed with nosocomial pneumonia in Georgian hospitals between December 2022 and February 2024. Gram-negative bacterial identification and ESBL determination were performed using the combination disk method, adhering to European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards. The analyses were conducted at TEST-IMP Laboratory and the Richard Lugar Center for Public Health Research to investigate the prevalence and resistance patterns of ESBL-producing versus non-ESBL Gram-negative bacteria. RESULTS: Among the 256 Gram-negative isolates, 201 (78.5%) were ESBL producers. Pseudomonas aeruginosa (63.7%), Acinetobacter baumannii (18.4%), and Klebsiella pneumoniae (17.9%) were the most prevalent. Non-ESBL producers accounted for 21.5%…
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.