A case of neonatal infection caused by Streptococcus agalactiae sequence type 283 in China’s mainland
Abstract
Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is a leading cause of neonatal sepsis, meningitis and pneumonia worldwide. Sequence type 283 (ST283), a hypervirulent lineage of GBS serotype III, has been implicated in large-scale foodborne outbreaks in Southeast Asia, particularly in Singapore, Hong Kong and Thailand.1,2 These outbreaks were primarily linked to consumption of or contact with raw freshwater fish, with >380 reported cases to date (Table S1, available as Supplementary data at JAC-AMR Online). While ST283 has been isolated from both humans and animals, its role in neonatal infections has been rarely documented, with only one previous case of early-onset disease (EOD) reported in Hong Kong and a total of four neonatal infections cases reported worldwide.3,4 No cases of ST283 infection have been reported in China’s mainland. Here, we describe the first case of EOD caused by ST283 in China’s mainland, providing evidence for maternal–neonate transmission and highlighting the potential for this clone to colonize mothers and infect neonates. The index case was a term neonate (38 + 3 weeks gestation, birth weight 3220 g) delivered vaginally to a healthy 26-year-old mother with no history of fever or infectious diseases. The neonate developed respiratory distress and lethargy within 6 hours of birth. Blood culture of the neonate grew S. agalactiae and the isolate was named as ZJSX030. The neonate achieved complete clinical recovery following a…
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