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Ribavirin therapy for severe COVID-19: a retrospective cohort study

Song Tong, Yuan Su, Yuan Yu, Chuang-Yan Wu, Jiuling Chen, Sihua Wang, Jinjun Jiang

International Journal of Antimicrobial Agents, 2020

138 citations

Abstract

Highlights • Patients in the experimental group received intravenous ribavirin versus supportive care only in the control group.• Ribavirin was not associated with reduced negative conversion time of SARS-CoV-2 PCR test compared with the control group.• Ribavirin did not reduce the mortality rate compared with the control group.

How strong is the evidence?

Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.

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