A study of 25 cases tested with the dermatophyte test strip after oral foslavuconazole treatment for tinea unguium
Abstract
The dermatophyte test strip (DTS) was developed in Japan as an im - munochromatographic method using an anti-dermatophyte mono - clonal antibody to detect tinea unguium antigen. 1 The DTS has been established as a diagnostic method for onychomycosis in several clinical trials. 2,3 All previous studies were conducted at the time of initial diagnosis; the DTS was not used to evaluate treatment effec - tiveness. This is because the DTS detects dermatophyte antigens, and it was assumed that if antigens remained in the nail after the fungus disappeared after treatment, the results would be positive. Therefore, no study has yet followed the post-treatment course with the DTS. Consequently, we observed the course of treatment after oral administration of fosravuconazole L-lysine ethanolate (fosravu - conazole, Sato Pharmaceutical Co., Ltd., Tokyo, Japan) with the DTS and KOH direct microscopy method (KOH method) over time. Twenty-five patients with toenail onychomycosis treated with oral fosravuconazole at the Ishida Dermatology Clinic were evalu - ated. The first toenail on either side of each patient was selected as the observation site, and the progress of the disease was observed during the course of treatment using the DTS and the KOH method. Specimens were collected from the nail's free edge using nail clip - pers, and the KOH method was performed using the tube method. 4 Following treatment completion, both tests were initiated when the opacity area was at least 2–3 mm from
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