Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation of hip, pelvic and long bone fractures: a systematic review and network meta-analysis
Abstract
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To review systematically the optimal administration and relative e@icacy of pharmacological interventions for preventing blood loss in definitive surgical fixation of the hip, pelvic and long bones. Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation of hip, pelvic and long bone fractures: a systematic review and network meta-analysis (Protocol) Copyright © 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 1 Cochrane Library Trusted evidence. Informed decisions. Better health. Cochrane Database of Systematic Reviews B A C K G R O U N D Description of the condition Traumatic injury and fracture is one of the world's leading causes of death and disability (Haagsma 2016). Acute orthopaedic injuries, including soH tissue, muscle and bone injuries, are the most common injuries sustained in accidents and the most likely form of traumatic injury to require hospitalisation (Clay 2010; Lang 2014; Lee 2005). In addition, orthopaedic injury may result in important individual and social disability and is associated with substantial economic and social costs (Clay 2010; Lang 2014; Williamson 2009). The ease with which bone fracture occurs is related to bone mineral density, which decreases with age. In younger people – with higher bone mineral density – high-impact accidents may result in fracture (Armas 2010); however, in older…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 10,000 participants or records.
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