Abstract 1954: Black-White differences in prospective serum metabolites and biochemical pathways associated with prostate cancer risk in a COMETS consortium project
Abstract
Prostate cancer incidence and mortality rates are substantially higher in Black men as compared with White men. It is unclear which exposures and biochemical pathways may explain this racial disparity. We examined the metabolomic profiles of prostate cancer risk by race within a subset of studies from the COnsortium of METabolomics Studies (COMETS). A meta-analysis of six cohort-based studies including 1,769 prostate cancer case-control sets and 831 serum metabolites was conducted using the multivariable logistic regression and random effects models. Overall, 11 metabolites were significantly associated with prostate cancer risk, including L-cystine (1-SD OR=0.77; P=0.009) and biliverdin (1-SD OR=1.12; P=0.017). The race-stratified analysis of chemical classes revealed that lipids were positively associated with prostate cancer risk only in White men, whereas amino acids were associated inversely primarily in Black men. The latter included metabolites related to tryptophan, lysine, and phenylalanine metabolism; e.g., the strongest metabolite being alpha-N-phenylacetyl-L-glutamine (1-SD OR=0.81; P=0.003), which is produced by Clostridial anaerobic bacteria in the gut. Lipids related to fatty acid metabolism were associated with higher prostate cancer risk in both Black and White men (e.g., docosahexaenoylcholine and 3-hydroxybutyroylglycine), and alpha-tocopherol was inversely associated in White men (1-SD OR=0.69; P=0.011). For other races combined, N-acetyltryptophan (1-SD…
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Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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