A systematic review of the secretome of skeletal muscle cells
Abstract
s / Osteoarthritis and Cartilage 27 (2019) S92eS516 S289 five were different at the time of ACL reconstruction surgery, six were different 6 months post-surgery, and eight were different 12 monthspost surgery. L-methionine, Glyoxylic acid, and Malonic acid concentrations were significantly lower across all time points in ACL injured cases compared to uninjuredmatched controls. L-Lysine concentrations were significantly higher in ACL injured cases across all time points. Succinic acid concentrations were significantly higher in ACL injured cases at the time of injury and at 6 months and 12months post-surgery. Arachidonic acid concentrations were significantly higher in ACL injured cases at the time of injury, the time of surgery, and 12 months post-surgery. The total percentage of explained variance by the first two principal components was 55.0% at the time of ACL injury, 58.0% at the time of ACL reconstruction surgery, 59.8% at 6months post-surgery, and 56.6% 12 months post-surgery. As demonstrated in the figure, modest separation was observed between ACL injured cases and uninjured matched controls at the first two time points (time of injury and surgery) and notable separationwas observed at the latter two time points (6 months and 12 months post-surgery). The proportion of cumulative explained variance with the first four principal components improved to 78.2% to 84.5% across all time points. Conclusions: Plasma concentrations for several metabolites appear to…
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Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 413 participants or records.
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