Inhaled aztreonam and an adapted delivery device in the treatment of cystic fibrosis
Abstract
Respiratory damage in cystic fibrosis (CF) is the result of a vicious circle of chronic infection, severe inflammation, and rapidly progressing bronchial obstruction. These processes are the main cause of high mortality associated with the disease. With age, the number of patients infected with non-fermenting gram-negative microflora increases. Pseudomonas aeruginosa is the most common gram-negative pathogen infecting the respiratory tract of patients with CF. The introduction of inhaled antipseudomonal antibiotics has changed the course of the disease and improved the lives of patients. The aim. The objective of the review was to study the role of aztreonam lysine for inhalation (AZLI) in the treatment of patients with CF based on an analysis of literary sources. Methods. A search for publications on AZLI was conducted in the Cochrane Database of Systematic Reviews, as well as in the PubMed and ClinicalTrials.gov databases using the queries “inhaled aztreonam” and “cystic fibrosis”. Results. The results of pre-registration clinical placebo-controlled phase 3 studies that led to AZLI’s Food and Drug Administration (FDA) approval were found and analyzed. The review also included reports of post-marketing studies comparing AZLI with the existing “gold standard” of inhaled antibacterial therapy for CF – inhaled Tobramycin. The role of the adapted AZLI delivery device, which creates an innovative drug-delivery device combination to achieve the maximum therapeutic effect, is…
Read the paper
Related studies
- Diagnosis and management of glutaric aciduria type I – revised recommendations
- EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas
- Consensus guidelines for the diagnosis and management of pyridoxine‐dependent epilepsy due to α‐aminoadipic semialdehyde dehydrogenase deficiency
- Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry
- Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin
- Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.