Effect of dried Ziziphus Jujube Consumption on Plasma Insulin, Blood Pressure, Oxidative Stress, and Advanced Glycation End Products in Diabetic Patients with Excess Weight: A Randomized Controlled Trial
Abstract
Background: Poor glycemic control and oxidative stress can accelerate the development of type 2 diabetes (T2D) complications. Recently, the potential benefits of herbs in managing T2D have received more attention. Therefore, we examined the effect of consuming dried Ziziphus jujube (ZJ) on plasma insulin, blood pressure, oxidative stress markers, and advanced glycation end products (AGEs) in T2D patients with excess weight. Methods: Forty-eight diabetic patients with excess weight were selected and randomly assigned to the ZJ group (n = 24) or the control group (n = 24). The case group received 30g of dried ZJ fruit daily for three months. Concentrations of fasting insulin, malondialdehyde (MDA), total antioxidant capacity (TAC), carboxymethyl lysine (CML), and blood pressure (BP) were measured. Results: After adjusting for baseline values, the ZJ group showed a significant decrease in systolic BP (up to 7 mmHg) and diastolic BP (up to 5 mmHg) compared to the control group (P < 0.05). Moreover, plasma insulin levels significantly decreased (up to 4.6 mIU/L) in the ZJ group compared to the control group (P < 0.05). However, there were no significant differences in the mean changes of plasma TAC, MDA, and CML between the two groups. Conclusions: The present study suggests that consuming 30g/day of dried ZJ fruit may improve some cardiometabolic profiles, including plasma insulin and blood pressure in T2D patients with excess weight. Trial registration: The present clinical…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 24 participants or records.
Read the paper
Related studies
- Diagnosis and management of glutaric aciduria type I – revised recommendations
- EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas
- Consensus guidelines for the diagnosis and management of pyridoxine‐dependent epilepsy due to α‐aminoadipic semialdehyde dehydrogenase deficiency
- Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry
- Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin
- Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.