Physical activity and markers of glycation in older individuals: data from a combined cross-sectional and randomized controlled trial (EXAMIN AGE)
Abstract
BACKGROUND
Advanced glycation endproducts (AGEs) are protein modifications that are predominantly formed from dicarbonyl compounds that arise from glucose and lipid metabolism. AGEs and sedentary behavior have been identified as a driver of accelerated (vascular) aging. The effect of physical activity on AGE accumulation is unknown. Therefore, we investigated whether plasma AGEs and dicarbonyl levels are different across older individuals that were active or sedentary and whether plasma AGEs are affected by high intensity interval training (HIIT).
METHODS
We included healthy older active (HA, n=38, 44.7% female, 60.1±7.7 years old) and healthy older sedentary (HS, n=36, 72.2% female, 60.0±7.3 years old) individuals as well as older sedentary individuals with increased cardiovascular risk (SR, n=84, 50% female, 58.7±6.6 years old). The SR group was randomized into a 12-week walking-based HIIT program or control group. We measured protein-bound and free plasma AGEs and dicarbonyls by UPLC-MS/MS at baseline and after the HIIT intervention.
RESULTS
Protein-bound AGE Nε-(carboxymethyl)lysine was lower in SR (2.6±0.5 μmol/L) and HS (3.1±0.5 μmol/L) than in HA (3.6±0.6 μmol/L; p<0.05) and remained significantly lower after adjustment for several potential confounders. None of the other glycation markers were different between HS and HA. HIIT did not change plasma AGEs and dicarbonyls in SR.
DISCUSSION
Although lifestyle interventions may act as important modulators of…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 84 participants or records.
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