Relationship between plasma l-lysine concentrations and levels of HIV-1 RNA
Abstract
The HIV/AIDS pandemic continues to be a major health problem with an estimated 34 million people living with human immunodeficiency virus, with 2.5 million new infections in 2011 and an estimated 1.7 million deaths from HIV-related illnesses in the same year.1,2 The development of an effective vaccine, new drugs, methods and approaches in the treatment of HIV-infection remains an urgent and pressing need. Conquering this enormous challenge demands further understanding of the biology of the virus, and its interaction not only with infected cells and the immune system, but also its negative impact on the development of metabolic disturbances.
The significant changes of the host protein and lipid metabolism, catabolic effect and the negative nitrogen equilibrium in HIV progression are widely appreciated,3-7 but there are few data in the literature about infection-related amino acid imbalance in HIV infected patients.8-13 At the same time, metabolic changes in patients with various pathological conditions14-25 lead to alterations in their amino-acid profiles and the concentrations of amino acids in the extracellular medium was found to be critical in the life cycle of some viruses.26-35 Observational studies indicate that amino acid imbalances are related to increased risk of rapidly progressing virus infections through changes of the protein homeostasis. Thus, amino acid profiles may be useful as early biomarkers of the physiological disturbances and disease progression.36,37…
Read the paper
Related studies
- Diagnosis and management of glutaric aciduria type I – revised recommendations
- EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas
- Consensus guidelines for the diagnosis and management of pyridoxine‐dependent epilepsy due to α‐aminoadipic semialdehyde dehydrogenase deficiency
- Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry
- Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin
- Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.