Role of angioprotective therapy in comprehensive postoperative rehabilitation of patients with cicatricial and paralytic laryngeal stenosis
Abstract
Abstract. One of the adverse events associated with surgical treatment of cicatricial and paralytic laryngeal stenosis is the development of edema in the early postoperative period. In this context, the use of highly effective medications in combination therapy aimed at reducing edema is of high priority. Such medications, which have proven effective in the treatment of other conditions, include the angioprotective drug L-lysine aescinate, which has a potent anti-inflammatory and anti-exudative effect. Objective. To improve the effectiveness of postoperative care in patients with cicatricial and paralytic laryngeal stenosis by including L-lysine aescinate into combination therapy. Patients and methods. The study involved 23 patients with a verified diagnosis of laryngeal stenosis, conducted at the Saint Petersburg Research Institute of Ear, Throat, Nose, and Speech from January to October 2025. Of the total number of patients, 13 had cicatricial stenosis, and 10 had paralytic laryngeal stenosis. Surgical interventions included laryngoplasty and laser microsurgery for laryngeal stenosis. In addition to comprehensive therapy in the perioperative period, L-lysine aescinate was administered intravenously daily for 5 days. Results and discussion. The use of L-lysine aescinate in the perioperative period helped reduce the severity of reactive phenomena in the surgical area. This is evidenced by a decrease in hyperemia and edema of the laryngeal mucosa, observed on the first day…
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