The integration of plasma non-target metabolomics and lipidomics analysis for the discovery of global developmental delay/intellectual disability biomarkers
Abstract
Background This study aimed to identify metabolic signatures and potential biomarkers for global developmental delay (GDD) and intellectual disability (ID) using plasma metabolomics and lipidomics. The research sought to evaluate the feasibility of these methods for early identification and to explore the underlying metabolic pathways associated with GDD/ID. Methods A liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS)-based method integrated with multivariate data analysis was employed to comprehensively characterize plasma metabolomics and lipidomics profiles in children diagnosed with GDD/ID compared to typically developing (TD) children. The study focused on identifying distinct metabolites and lipids that could differentiate GDD/ID from TD children. Results The analysis revealed that a combination of 11 metabolites and lipids could effectively discriminate between GDD/ID and TD children. Receiver operating characteristic (ROC) analysis identified several potential biomarkers for GDD/ID. In positive ion mode, glycerophosphocholine (AUC = 0.899) and sphinganine (AUC = 0.859) showed diagnostic potential. Negative ion mode analysis revealed five biomarkers, notably 2-ketohexanoic acid (AUC = 0.912) and N-acetyl-L-aspartic acid (AUC = 0.870). Lipidomics analysis highlighted two high-performance biomarkers: diacylglycerol (DAG) (16:0/16:0) (AUC = 0.956) and DAG (16:0/18:0) (AUC = 0.949). Key metabolic pathways associated with GDD/ID included D-glutamine,…
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