Plasma advanced glycation products are associated with increased risk of depression in middle-aged and elderly Chinese adults
Abstract
Depression is becoming a critical health challenge for the middle-aged and elderly populations. Existing evidence on the associations between body accumulations of advanced glycation end products (AGEs) and depression remain inconsistent. We hypothesized that plasma AGEs concentration might be positively correlated with the incidence of depression in middle-aged and elderly adults. In this cross-sectional study with 586 participants (201 males and 385 females, mean age: 62.18 years old) from Suzhou city, depression was assessed via the Center for Epidemiologic Studies Depression scale 10-item version (CES-D-10). Plasma AGEs of free Nε-carboxymethyl-L-lysine (CML), Nε-(1-carboxyethyl) lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1), as well as protein bound CEL and CML were measured with ultraperformance liquid chromatography and tandem mass spectrometry. Multivariate linear regression analysis and logistic regression analysis were utilized to determine the associations between specific plasma AGEs and CES-D-10 score and the incidence of depression, respectively. The incidence of depression was 8.02%. Plasma protein bound CEL and CML concentration were positively correlated with CES-D-10 score (CEL: β=0.12, P=0.018; CML: β=0.14; P=0.034) in the linear regression analysis. Compared to those below the median concentration of bound CEL and CML, participants with bound CEL and CML concentration above the median had increased risk of depression [ORs…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 586 participants or records.
Read the paper
Related studies
- Diagnosis and management of glutaric aciduria type I – revised recommendations
- EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas
- Consensus guidelines for the diagnosis and management of pyridoxine‐dependent epilepsy due to α‐aminoadipic semialdehyde dehydrogenase deficiency
- Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry
- Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin
- Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.