1268-P: P-tau217 and Cognitive Function in Long-Duration Type 1 Diabetes
Abstract
Introduction and Objective: People with diabetes have an increased risk of dementia. Plasma Phosphorylated Tau 217 (pTau217), a novel marker of Alzheimer’s disease (AD), hasn’t been examined in type 1 diabetes (T1D). Joslin Medalists (mean age 71 and T1D ≥50 years) had previously shown worse cognitive function compared to age-matched non-diabetic people (NDM). Thus, we examined the associations of pTau217 with cognitive function in Medalists.
Methods: Plasma pTau217 (S-Plex, Meso Scale Discovery) was assayed in 164 Medalists who had undergone cognitive testing for psychomotor function (Grooved Pegboard), immediate and delayed recall (RAVLT), executive function (Delis Kaplan), and working memory (Wechsler). Poor cognitive function was defined as 1.5 SD deviation from means of NDM group. High pTau217 was defined using ≥7.3 pg/ml as the optimal cutoff-point for AD risk published previously. Associations between pTau217 and cognitive function were tested cross-sectionally in stepwise logistic regression models adjusted by age, sex, education, T1D duration, HbA1c, lipids, eGFR, and advanced glycation end-products (AGEs: carboxymethyl- and carboxyethyl-lysine).
Results: Higher pTau217 associated with male sex, older age, longer diabetes duration, worse lipids and renal function, higher IL1β and AGEs, but not with HbA1c or continuous glucose monitoring metrics including hypoglycemia. Odds of having pTau217 ≥7.3 pg/ml were higher (p<0.05) among those with poor immediate (OR=3.8) and…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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