Outcomes of Microsporidial Keratoconjunctivitis Management During a Seasonal Outbreak at a Tertiary Eye Hospital
Abstract
Abstract Background : Microsporidial keratoconjunctivitis (MKC) is relatively common, frequently misdiagnosed and occasionally persistent to conservative treatment. This paper aimed to report the outcome of treatment regimen in the management of microsporidial keratoconjunctivitis during Monsoon season in a tertiary eye hospital in Nepal. Methods : The study was a retrospective case series. Twenty-two patients with MKC were studied regarding the clinical response toward the combination of Moxifloxacin 0.5%, Voriconazole 1%, and oral Albendazole 400mg. Corneal epithelial debridement was done selectively in case with confluent and collective MKC lesions. Topical Prednisolone Acetate 1% was added when the MKC lesion resolved. All cases were observed during follow-up regarding the duration from treatment to the resolution of MKC lesions and the resolution of all corneal lesions. Results : Mean ± SD age of participants was 38.7 ± 13.1 years. Male and female participants accounted for 59.1% and 40.9%, respectively. Gram’s stain positive for microsporidial spores was presented in 72.7%. Exposure to topical steroid, rain water and mud were found only in 59.1%, 18.2% and 13.6%, respectively. Median duration to microsporidial lesions resolution (min to max) and medianduration to total resolution (min to max) were 5.0 (2.0 to 9.0) days and 14.0 (7 to 21) days, respectively. No patient with debridement had persistent epithelial defect or secondary infection. All patients did not have…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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