Clinical Characteristics, Susceptibility Profiles, and Treatment of Rapidly Growing Mycobacteria in a Tertiary General Hospital in China
Abstract
Abstract Background There is a lack of epidemiological data, antimicrobial resistance profiles and clinical management information on clinical rapidly growing mycobacteria (RGM) infections among healthcare facilities at various levels in Henan Province, China. Methods In this study, 36 non-duplicate RGM infection cases were collected from The First Affiliated Hospital of Zhengzhou University, and strains were identified through MALDI-TOF MS and susceptibility testing was performed with broth microdilution method. Results Among these isolates, the most common species was Mycobacterium abscessus complex (58.3%), followed by M. fortuitum complex (30.6%) and M. smegmatis complex (11.1%). 43.2% were collected from skin and soft tissue pus, followed by peripheral venous blood (24.3%), bronchoalveolar lavage fluid (16.2%), ranked among the top three. Simultaneously, all 36 RGM strains were susceptible to amikacin. The isolates were all susceptible to amikacin and with low MICs to tigecycline. M. abscessus subsp. abscessus exhibited 65% susceptibility rate but 75% induced resistance rate to clarithromycin, and 75% resistance rate to moxifloxacin, while M. fortuitum displayed 0 and 100% sensitivity to clarithromycin and moxifloxacin, respectively. Various strains demonstrate diverse resistance profiles. There were 44.4% cases established as simple skin and soft-tissue infection, 19.4% as simple pulmonary infection, and 11.1% as pulmonary and bloodstream infection. 50% of cases…
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