Experimental Study on Anti-Infection and Promotion of Macrophage Polarization for the Treatment of Traumatic Bone Infection Using Rifampicin/Moxifloxacin-Loaded PLGA Microspheres
Abstract
BACKGROUND
Traumatic osteomyelitis remains a prevalent and intractable clinical disorder in orthopedics. Treatment of this condition is severely hindered by multiple factors, including multidrug-resistant bacterial infections (predominantly methicillin-resistant Staphylococcus aureus, MRSA), the blood-bone barrier, infection-induced bone necrosis, and the internalization capacity of bone cells. Current therapeutic strategies mainly consist of debridement, systemic antibiotic administration, and local sustained-release antibiotic delivery. Local biodegradable materials with sustained antibiotic release may help maintain effective antibacterial exposure at infectious sites and may be associated with favorable changes in the inflammatory microenvironment during infection resolution and tissue repair.
MATERIALS AND METHODS
Our research team has previously constructed rifampicin/moxifloxacin-loaded Poly(lactic-co-glycolic acid) (PLGA) sustained-release microspheres and validated their favorable sustained-release characteristics and antibacterial properties in vitro. In the present study, we further investigated their therapeutic efficacy against traumatic osteomyelitis, with a focus on infection-related pathological changes and macrophage polarization-associated inflammatory responses. A murine femoral traumatic osteomyelitis model was established, and animals were assigned to three groups (control, model, and rifampicin-moxifloxacin (RM)-PLGA treatment) for comparative…
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