Nummular Keratitis Following Epidemic Keratoconjunctivitis: A Guide to Managing Subepithelial Infiltrates
Abstract
Introduction: Epidemic keratoconjunctivitis (EKC) is a highly contagious viral ocular surface infection characterized by conjunctivitis with corneal involvement. Although EKC is usually self-limiting, corneal sequelae can persist for weeks to months and may significantly impact the quality of life.
Aim: To analyze the effectiveness of the treatment protocol and healing of nummular keratitis after EKC.
Methods: This is a retrospective observational study of eight patients with a history of viral conjunctivitis and EKC. Diagnosis and management in the acute stage relied solely on clinical evaluation, as laboratory testing remains significantly limited, often resulting in underdiagnosis and inadequate treatment. Thorough slit lamp evaluation, fluorescein staining, and visual acuity assessment were performed for all patients during follow-up. These cases of EKC were initially managed suboptimally elsewhere and later presented with decreased vision, photophobia, and nummular subepithelial infiltrates.
Results: All patients were treated with a tapering course of low-dose topical corticosteroids, leading to complete resolution in six cases (75%), while two (25%) required long-term topical cyclosporine therapy.
Conclusion: This study highlights the importance of close monitoring of patients with acute infectious conjunctivitis until full resolution, enabling timely initiation of topical immunosuppressive therapy when indicated for nummular subepithelial infiltrates. Our study…
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.