The microbiology of moxifloxacin
Abstract
Moxifloxacin is a new group IV 8-methoxyquinolone. It is slightly less active than ciprofloxacin against enterobacteria and much less effective against P. aeruginosa. However, moxifloxacin is clearly better than ciprofloxacin in treating atypical microorganisms and especially anaerobic bacteria and aerobic Gram-positive cocci, including methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae. In recent years there has been an increase in the resistance of some respiratory pathogens to beta-lactam and macrolide antibiotics. Bearing in mind that moxifloxacin is well tolerated, its microbiological properties and pharmacokinetic characteristics mean that it will undoubtedly be useful in treating certain infections, particularly community-acquired respiratory infections, hospital-acquired respiratory infections caused by aerobic Gram-positive cocci, infections caused by anaerobic bacteria and skin infections. Studies have shown that moxifloxacin is effective and well tolerated in all of these conditions.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.