Synthesis of Moxifloxacin
Abstract
Moxifloxacin was synthesized from pyridine-2,3-dicarboxylic acid via dehydration, benzylamination,cyclization, reduction of pyridine ring and carbonyl groups, resolution and debenzylation to afford (S,S)-octahydro-6H-pyrrolo[3,4-b]pyridine which condensed with the boric chelate of the quinolone intermediate and then hydrolysis with anoverall yield of 43.3%.
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