Convulsions associated with moxifloxacin
Abstract
Fluoroquinolones are generally well tolerated but can cause central nervous system (CNS) toxicities.1 We are unaware of published case reports of moxifloxacin causing new-onset convulsions, though one case associating the drug with seizures in a patient with a history of epilepsy has been reported.2 We report a case of new-onset convulsions associated with the use of moxifloxacin. A 45-year-old perimenopausal woman appeared at an occupational medicine clinic after completing a 14-day course of cephalexin for persistent sinus symptoms, which included sinus and ear pain, congestion, and low-grade fever. The clinic visit revealed a purulent discharge from her left tympanic membrane on otoscopic examination, but the remainder of the physical examination, including neurologic testing, was normal. The patient had a history of treated hyperthyroidism and seasonal allergies. Moxifloxacin 400 mg orally once daily was prescribed. The patient returned to the same clinic the next day after taking one dose of moxifloxacin. She reported that within one hour of taking the dose, she felt nauseated, nervous, anxious, and agitated. She described feeling her heart racing and pounding. She also described pain and cramps in her legs, beginning two hours after the dose, followed by shaking tremors and an inability to control body movements, which lasted for 10 minutes.
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