Green RP-HPLC method for simultaneous determination of moxifloxacin combinations: Investigation of the greenness for the proposed method
Abstract
Abstract The green analysis has acquired increased importance in different fields including pharmaceutical analysis. However, the majority of chromatographic methods still use large volumes of toxic and non- degradable organic solvents. This study displays a green HPLC assay method for simultaneous estimation of two moxifloxacin combinations: moxifloxacin/dexamethasone and moxifloxacin/prednisolone. Simultaneous separation of each of moxifloxacin binary mixtures was achieved on a reversed phase Thermo scientific MOS-1 Hypersil C8 column (250 mm × 4.6 mm i.d., 5-μm particle size) using an eco-friendly isocratic eluent; ethanol: water containing 0.05% triethanolamine (90:10, v/v, pH 4.5). The assay was completed for each combination within
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