Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities
Abstract
BackgroundThe drug-metal complexes are used to control the growth of pathogens and parasites which are harmful to humans. Moxifloxacin (MOX) is a new fourth generation 8- methoxy fluoroquinolone. Its chemical name is [1-cyclopropyl-7-(S,S)-2,8-diazabicyclo(4.3.0)- non-8-yl-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinoline carboxylic acid hydrochloride]. Many researchers have reported Moxifloxacin-metal complexes with transition metals and studied their biological applications. We have synthesized novel moxifloxacin- Au(III) and Ag(I) metal complexes ([Au(MOX) 2 (Cl) 2 ].2H 2 O and [Ag (MOX) 2 ].2H 2 O), characterized, and found their biological activities.MethodsMoxifloxacin- Au(III) and Ag(I) metal complexes were prepared by adding corresponding aqueous solutions of Au(III) and Ag(I) metal salts to methanolic solution of Moxifloxacin. These metal complexes were characterized by physio-chemical techniques like UV-Vis, 1 H- NMR, FTIR, XRD, DSC, TGA, SEM and microanalytical data. The disc diffusion method was used to study the antibacterial activity of the Moxifloxacin-metal complexes.ResultsThe structural assessment of these complexes has been carried out based on physio- chemical and spectroscopic methods. The powder X-ray diffraction data of the metal complexes revealed moderate crystallinity. SEM analysis confirms that [Ag(MOX) 2 ].2H 2 O complex has small rods like morphology whereas [Au(MOX) 2 (Cl) 2 ].2H 2 O has well crystalline rods like morphology. The results from DSC…
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.