Efficacy and Safety Rifapentine-Containing Regimen for Drug Sensitive Tuberculosis: Systematic Review and Meta-Analysis
Abstract
resistant TB with approximately 410000 cases of multidrug resistant/rifampicin-resistant TB globally 3 .Therefore, tuberculosis treatment needs to be carried out in a shorter and easier manner than the current six-month daily regimen, thereby increasing adherence and potentially reducing adverse drug effects 1,4,5 .Rifapentine, a cyclopentyl ring-substituted rifamycin with a longer half-life than rifampicin, is active against M. tuberculosis.Therefore, the potential of rifapentine for enhanced treatment has been explored.The US Food and Drug Administration approved rifapentine for the treatment of active tuberculosis, at a dose of 1200 mg weekly in combination with other antituberculosis drugs 6,7 .Preclinical research on mouse models has demonstrated that three months of daily rifapentine therapy is sufficient to cure patients.In tuberculosis treatment, the rifapentinebased regimen for 4 months containing moxifloxacin was not inferior to the standard regimen for 6 months 8,9 .The combination of rifapentine and moxifloxacin was active in ABSTRACT INTRODUCTION Newer regimens are needed and expected to have a shorter therapeutic time to increase drug adherence to completion in drug sensitive tuberculosis (DS-TB) patients. METHODSWe conducted first a systematic review and meta-analysis of prior studies to evaluate the effectiveness of rifapentine-containing regimens in treating DS-TB patients.Various search engines and keywords based on the PICOS framework for article selection…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.