Antibiotic Resistance Profile of Clinical Strains of Enterococci from Secondary/Persistent Endodontic Infections: What do We Know? A Systematic Review of Clinical Studies
Abstract
BACKGROUND
Enterococcus faecalis is the most common enterococcal species associated with infective endocarditis and one of the most commonly detected bacteria in cases of secondary/persistent endodontic infection (SPEI). Antimicrobial resistance is a global public health concern.
OBJECTIVE
This review aimed to answer the following research question: "Is there a change in the antibiotic resistance profile in clinical strains of E. faecalis over the years?". P (population) - patients with SPEI, I (intervention) -endodontic retreatment, C (comparison) -not included, O (outcome) - profile of Enterococci resistance and susceptibility to systemic antibiotics (SA) used.
METHODS
Two authors independently performed study selection, data extraction and risk of bias assessment. The literature search was conducted using the following electronic databases: PubMed, Scopus, EMBASE, Web of Science and Medline. Clinical studies in which E. faecalis strains were isolated to assess their antimicrobial resistance were included.
RESULTS
Eleven clinical trials were included. Overall, E. faecalis isolated from teeth with SPEI presented an intermediate resistance to 16 antibiotics. In recent years, E. faecalis showed a little resistance to Amoxicillin (without Clavulanate) and Benzylpenicillin. Erythromycin and Rifampicin presented an increase in the intermediate-resistance status between the first and the last studies. E. faecium presented intermediate-resistance results.
CONCLUSION
The most…
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