Analisis pola DAN efektivitas terapi antibiotik empiris terhadap perbaikan klinis pada pasien keratitis bakterial rawat jalan
Abstract
Abstract. Bacterial keratitis is a corneal infection that may lead to pain, visual impairment, and even permanent blindness if not promptly and appropriately treated. In outpatient settings, empirical antibiotic therapy is often chosen as the initial management because culture and sensitivity results require more time, whereas delays in therapy may worsen the clinical condition. This study aims to evaluate the effectiveness of empirical antibiotic therapy on clinical improvement and follow-up visits in patients with bacterial keratitis. A systematic literature review was conducted by searching PubMed and Google Scholar for articles published between 2015 and 2025. From 242 articles identified, 12 met the inclusion criteria and were analyzed further. The findings revealed that moxifloxacin and ciprofloxacin were the most frequently prescribed topical antibiotics, with treatment durations ranging from 7 to 21 days. Overall, empirical therapy was shown to accelerate clinical improvement, particularly within the first week of treatment. However, evidence supporting a reduction in follow-up visit frequency remains limited and presents varied results across studies, potentially due to differences in study design and patient conditions. Factors such as treatment regimen, duration of therapy, disease severity, and patient characteristics were also reported to influence the variability in outcomes. In conclusion, empirical antibiotic therapy appears to be clinically effective for…
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.