Use of Povidone-Iodine Solution for Intraoperative Antisepsis: A Systematic Review
Abstract
Antisepsis is a critical aspect of ocular surgery, particularly in intraocular procedures, due to the high risk of postoperative infections. Povidone-iodine is widely recognized for its broad-spectrum antimicrobial properties. This systematic review evaluates the intraoperative use of povidone-iodine applied to the conjunctiva in ocular surgeries. A systematic literature search was conducted using PubMed, Scopus, and Google Scholar for randomized controlled trials (RCTs) published between 2009 and 2023 in English that involved individuals who had undergone an ophthalmological intervention. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and a PRISMA flow diagram was used to illustrate the study selection process. Keywords used included the following: ("Povidone-iodine" OR "Betadine") AND ("Conjunctiva" OR "Ocular surgery"). Studies were selected based on predefined inclusion criteria focusing on the intraoperative antiseptic application of povidone-iodine in human ocular procedures, omitting conference abstracts or unpublished studies. Four RCTs met the inclusion criteria. The evidence base is limited by the small number of included RCTs, which restricts the statistical power and generalizability of the findings. This small sample increases susceptibility to methodological bias, reduces the reliability of pooled estimates, and limits the ability to explore heterogeneity. Furthermore, the potential for publication bias…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.