Multifunctional moxifloxacin and essential oil loaded sodium alginate/thiolated karaya gum hydrogel dressings for improved wound healing
Abstract
Numerous efforts have been done to develop wound dressings for effective wound treatment, remains a considerable challenge. The aim of current research work was to prepare multifunctional sodium alginate/thiolated karaya gum hydrogel dressings containing moxifloxacin in combination with artemesia/cedarwood essential oil. Thiolation of karaya gum was achieved by esterification reaction with 3 mercapto-propionic acid and synthesis of blended sodium alginate and thiolated karaya gum hydrogel films without (S1/TK1) and with moxifloxacin and artemesia/cedarwood oil (S1/TK1.DA1, S1/TK1.DC1) was achieved using solvent casting technique and were evaluated for fourier transform infrared spectrum and thermogravimetric analysis. Increasing the concentration of thiolated karaya gum substantially enhanced the bioadhesion, with a 350 % increase in bioadhesion-force and 353 % improvement in bond-strength while exhibiting balanced mechanical properties with an increase rate of 166 % in tensile strength and 73 % in percent-elongation. Incorporation of both moxifloxacin and artemesia/cedarwood oil also considerably enhanced the antibacterial activity of Optimized S1/TK1.DA1 and S1/TK1.DC1 formulations by 286 % and 253 % against s. aureus and 367 % and 269 % against e. coli respectively. Furthermore 2, 2 - di phenyl picryl hydrazyl (DPPH) and superoxide anion scavenging potential of S1/TK1.DA1 and S1/TK1.DC1 were enhanced by 1587 %, 1379 % and by 1384 % and 1245 % respectively. In vivo wound…
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