Metal chelation approach synergized with surfactant for spectrofluorimetric assay of moxifloxacin with method greenness evaluation
Abstract
This work deals with devising a quick and easy method for moxifloxacin assay using a sensitive spectrofluorimetric technique. The method benefited from the interaction of the aforementioned drug with the aluminum cation which form a stable chelate with a high fluorescence characteristic. Further improvement in the fluorescence was achieved upon the addition of sodium lauryl sulfate. The experimental parameters of the reaction were carefully investigated. The fluorescence intensity was measured at a wavelength of 478 nm after excitation at 365 nm. A linear relationship between the intensity of fluorescence and moxifloxacin concentration was in the range of 10–200 ng mL− 1. The developed method was highly sensitive since the lower limit of detection was 2.2 ng mL− 1. Application of the suggested spectrofluorimetric method included the analysis of commercial tablet dosage forms containing the cited drug. In addition, human plasma samples spiked with the drug were analyzed, and good recovery was obtained. Moreover, the environmental friendliness of the developed procedure was confirmed through employing AGREE and GAPI approaches.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.