Voltammetry Determination of Moxifloxacin, Paracetamol, and Vitamin C in Serum Samples Using PEDOT/CNT‐ILC/Fe3O4 Nanocomposite Sensor
Abstract
An efficient electrochemical sensor is presented for the detection of moxifloxacin (MXF) separately and simultaneously with paracetamol (PAR) and vitamin C (VC) in human serum samples. Combination therapy formed from moxifloxacin and paracetamol (PAR) is needed for treating patients diseased by bacterial infections. VC supports the immune system and acts as an antioxidant to eliminate harmful substances. The design of the electrochemical sensor is achieved via layer‐by‐layer modification of a glassy carbon electrode surface (GCE) with poly(3,4‐ethylenedioxythiophene) (PEDOT), a mixture of multiwalled carbon nanotubes and ionic liquid crystals (CNT‐ILC), and Fe3O4 nanoparticles (Mag). The synergistic interactions between the components significantly improve the overall sensor performance for MXF, PAR, and VC detection with kinetically and thermodynamically boosted oxidation processes. The sensor has good anti‐interference capability, repeatability, stability, reproducibility, and large conductive active surface area. The sensor reaches detection limits as low as 6.1, 3.8, and 8.5 nM for the determination of MXF, PAR, and VC, respectively. Large peak potential separations of 280 and 600 mV between VC‐PAR and PAR‐MXF are attained. The analysis of drugs in pharmaceutical formulations and serum samples is effectively realized with accepted recovery percentages.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.