Idiosyncratic Drug-Induced Neutropenia Following Pantoprazole, Moxifloxacin Hydrochloride, and Rifabutin Treatment for Helicobacter pylori: A Case Report
Abstract
Idiosyncratic drug-induced neutropenia (IDIN) is a rare but potentially life-threatening condition characterized by immune-mediated neutrophil destruction. We present the case of a 45-year-old female who developed severe neutropenia following a 14-day Helicobacter pylori treatment regimen containing pantoprazole, moxifloxacin hydrochloride, and rifabutin. The patient initially presented with a one-week history of fever, chills, and myalgias, with laboratory findings revealing leukopenia and thrombocytopenia. Based on the temporal relationship between medication use and symptom onset, drug-induced neutropenia was suspected. Further follow-up and workup were completed, and the patient’s symptoms resolved within one week of stopping the treatment regimen. Repeat bloodwork at this time also demonstrated recovery of her white blood cell count, further supporting the diagnosis. Rifabutin, though an effective alternative for antibiotic-resistant H. pylori infections, has been associated with cases of hematologic complications, including neutropenia, as seen in this patient. In 2019, rifabutin was approved for the treatment of H. pylori, and its use is likely to increase. This case, therefore, highlights the importance of early recognition of IDIN as a potential adverse effect of rifabutin treatment, particularly in patients presenting with acute-onset, unexplained fever and hematologic abnormalities. Early detection, discontinuation of the offending agent, and close hematologic…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.