Moxifloxacin and its USE in odontogenic infections. an alternative for patients with penicillin allergies? literature review
Abstract
Maxillofacial infections of odontogenic origin are a frequent cause of dental emergencies, primarily caused by caries, periodontal disease, and dentoalveolar abscesses. These infections, which can vary in severity and spread throughout facial spaces, sometimes require surgical management and intravenous drug treatment in hospitals. The oral bacterial flora is predominantly polymicrobial, with a majority of streptococci and the presence of staphylococci and anaerobic bacteria. Regarding antimicrobial treatment, penicillins (PEN) continue to be accepted as the first-line option, growing resistance has prompted the search for alternatives such as clindamycin and quinolones, with moxifloxacin being particularly notable for its broad spectrum and effectiveness against oral pathogens. This study evaluates the in vitro and in vivo efficacy of moxifloxacin in the treatment of maxillofacial infections, including maxillary sinusitis, abscesses, and cellulitis of odontogenic origin.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.